Cancer Cell Line Encyclopedia Metabolomics

A compilation of gene expression chromosomal copy number and massively parallel sequencing data from 947 human cancer cell lines.

Cancer cell line encyclopedia metabolomics. Specifically metabolomics is the systematic study of the unique chemical fingerprints that specific cellular processes leave behind the study of their small molecule metabolite profiles. When coupled with pharmacological profiles for 24 anticancer drugs across 479 of the cell lines this collection allowed identification of genetic lineage and gene expression based predictors of drug. By integrating intracellular metabolic profiles of 54 cancer cell lines with. Here we describe the cancer cell line encyclopedia ccle.

Cell density for metabolomics experiments was. The cancer cell line encyclopedia is a database of gene expression genotype and drug sensitivity data for human cancer cell lines. To further understand the metabolic diversity of cancer we profiled 225 metabolites in 928 cell lines from more than 20 cancer types in the cancer cell line encyclopedia ccle using liquid. The ccle cancer cell line encyclopedia project is a collaboration between the broad institute and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models to develop integrated computational analyses that link distinct pharmacologic.

2012 the cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. The metabolome represents the complete set of metabolites in a biological cell tissue organ or organism which are the end products of cellular processes.